Basal Ganglia Disorders
(Frankfurt 2-3 Jul 2007)
141k
Chair: Nicolas LeNovere, Cambridge, UK
Based on the evaluation
criteria, the participants discussed and eventually agreed on a ranking of
disorders suitable for a systems biology approach: Parkinson disease, drug addiction,
and schizophrenia. Morover the workshop produced a commented survey of
bottlenecks.
Inflammatory Diseases
(Frankfurt 7 Sep 2007)
150k
Chair: Thomas Höfer, Heidelberg, Germany
Primary immune cells are
considered good models due to the high standard of available cell culture
technologies and the access to in vivo models, i.e. KO mice. The following disease-relevant
functions of certain cell types were discussed with respect to the amenability
for SB approaches: T-cell activation, T-cell survival/ renewal, T-cell memory,
macrophage activation, neutrophil functions.
Dynamic Principles of Cellular Function
(Frankfurt 24-25 Oct 2007)
152k
Chair: Olaf Wolkenhauer, Rostock,
Germany
The elucidation of the
functional organisation of living systems is obviously indispensable for
understanding malfunctions, i.e. disease conditions. Adressing the implications
of this approach the experts discussed fundamental aspects of the dynamics of
cell function: Model integration, Merging Signalling, Metabolism and Gene
Expression, Crossing Levels, Do modules exist naturally or are they organising
principles.
Cancer
(Nice 8-9 Nov 2007)
144k
Chair: Niels Blüthgen, Manchester,
UK
The participants expect SB to
contribute useful information, especially on colorectal carcinoma (CRC) since there
is a high medical need, a good knowledge base from all stages of the disease and there is access to clinical material. SB can possibly help to better understand the dynamics of metastasis metabolism.
Diabetes
(Berlin 30-31 Jan 2008)
166k
Chair: Pierre DeMeyts, Copenhagen, Denmark
For decades traditional approaches have failed to provide an understanding of the pathogenesis of type 2 diabetes.There are numerous puzzles left, e.g. the unclear correlation of diabetes and obesity. There is a high need for integrative approaches in order to understand the multi-layered complexity. The complete nomenclature of the common alleles that in unfavorable combination predispose to disturbed metabolism will reveal new critical nodes/pathways in metabolic regulation. Connecting these dots is regarded as the premier contribution of systems biology generating useful models.
The Cancer-Ageing Link
(Paris 12 Feb 2008)
119k
Chair: Ingrid van Leeuwen, Dundee, UK
The causal mechanisms of ageing and the interplay of putative key factors are not well understood. Systems biology approaches are expected to complement ongoing research efforts and to provide deeper insights into some specific questions addressed in the report.
Chronobiology
(Paris 13 Feb 2008)
111k
Chair: Hanspeter Herzel, Berlin, Germany
The circadian clock and many diseases very likely are mechanistically connected. Fundamental questions regarding the relation of the circadian clock, cell cycle, and metabolic rhythm call for intensive research. Fortunately, oscillatory biological processes represent a clear case for systems biology, and modelling is expected to help unravel many of the still unknown mechanisms.
Colon Cancer
(Barcelona 8-9 Apr 2008)
Chair: Olaf Wolkenhauer, Rostock, Germany
Science Policy Briefing workshop
(Barcelona 10-11 Apr 2008)
566k
SPB document
Chair: Olaf Wolkenhauer/ Thomas Bruhn
Based on the workshop's findings the ESF Science Policy Briefing 35
Advancing Systems Biology for Medical Applications
was published on the web on 23 December 2008 (see
ESF publications site
)
Challenges in Medical Systems Biology
(Costa Adeje, Tenerife 2 Oct 2008)
254k
Chair: Olaf Wolkenhauer, Rostock, Germany
The participants discussed which 'grand challenges' – be it scientific or organisational – they expect medical systems biology (MSB) to meet in the coming years. They also took the opportunity to give their individual views on some 40 issues listed in a questionnaire.
EU-US Trans-Atlantic Summer School/ Workshop
Cancer Systems Biology
(Rostock, Germany 7-10 June 2009)
556k
